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Article

STAT3 Protein Regulates Vascular Smooth Muscle Cell Phenotypic Switch by Interaction with Myocardin.

The Journal of biological chemistry - 7 Aug 2015

Liao Xing-Hua, Wang Nan, Zhao Dong-Wei, Zheng De-Liang, Zheng Li, Xing Wen-Jing, Ma Wen-Jian, Bao Le-Yuan, Dong Jian, Zhang Tong-Cun

Abstract excerpt

The JAK-STAT3 signaling pathway is one of the critical pathways regulating cell proliferation, differentiation, and apoptosis. Myocardin is regarded as a key mediator for the change of smooth muscle phenotypes. However, the relationship between STAT3 and myocardin in the vascular smooth muscle cell (VSMC) phenotypic switch has not been investigated. The goal of this study was to investigate the molecular...

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Identifiers

PMID: 26100622
DOI: 10.1074/jbc.M114.630111
PMCID: PMC4528129

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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