Article
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.
Neurology - 9 Aug 2005
Dickerson B C, Salat D H, Greve D N, Chua E F, Rand-Giovannetti E, Rentz D M, Bertram L, Mullin K, Tanzi R E, Blacker D, Albert M S, Sperling R A
Abstract excerpt
OBJECTIVE: To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI). METHODS: Three groups of older individuals were studied: 10 cognitively intact controls, 9 individuals at the mild end of the spectrum of MCI, and 10 patients with probable Alzheimer disease (AD). Subjects performed a face-name associative...
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