Article
Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue.
Molecules and cells - 1 Feb 2011
Choi Sun-Hye, Shin Tae-Joon, Lee Byung-Hwan, Hwang Sung Hee, Lee Sang-Mok, Lee Byung-Cheol, Park Cheol-Seung, Ha Tal Soo, Nah Seung-Yeol
Abstract excerpt
Ginsenosides, active ingredients of Panax ginseng, are known to exhibit neuroprotective effects. Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels are key modulators of cellular excitability of neurons and vascular smooth muscle cells. In the present study, we examined the effects of ginsenosides on rat brain BK(Ca) (rSlo) channel activity heterologously expressed in Xenopus oocytes to elucidate the...
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