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Article

Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties.

Scientific reports - 30 Nov 2015

Zhao Ning, Dong Qian, Qian Cheng, Li Sen, Wu Qiong-Feng, Ding Dan, Li Jing, Wang Bin-Bin, Guo Ke-fang, Xie Jiang-jiao, Cheng Xiang, Liao Yu-Hua, Du Yi-Mei

Abstract excerpt

Lovastatin is a member of Statins, which are beneficial in a lot of immunologic cardiovascular diseases and T cell-mediated autoimmune diseases. Kv1.3 channel plays important roles in the activation and proliferation of T cells, and have become attractive target for immune-related disorders. The present study was designed to examine the block effect of Lovastatin on Kv1.3 channel in human T cells, and to clarify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26616555
DOI: 10.1038/srep17381
PMCID: PMC4663632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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