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Article

Residual NADPH oxidase and survival in chronic granulomatous disease.

The New England journal of medicine - 30 Dec 2010

Kuhns Douglas B, Alvord W Gregory, Heller Theo, Feld Jordan J, Pike Kristen M, Marciano Beatriz E, Uzel Gulbu, DeRavin Suk See, Priel Debra A Long, Soule Benjamin P, Zarember Kol A, Malech Harry L, Holland Steven M, Gallin John I

Abstract excerpt

BACKGROUND: Failure to generate phagocyte-derived superoxide and related reactive oxygen intermediates (ROIs) is the major defect in chronic granulomatous disease, causing recurrent infections and granulomatous complications. Chronic granulomatous disease is caused by missense, nonsense, frameshift, splice, or deletion mutations in the genes for p22(phox), p40(phox), p47(phox), p67(phox) (autosomal chronic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21190454
DOI: 10.1056/NEJMoa1007097
PMCID: PMC3069846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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