Article
Clinical and molecular significance of flow cytometric analysis for reactive oxygen species production and residual p67phox expression in p67phox-deficient chronic granulomatous disease.
Scandinavian journal of immunology - 1 Jul 2024
Miyazawa Hanae, Muraoka Masahiro, Matsuda Yusuke, Toma Tomoko, Morio Tomohiro, Shigemura Tomonari, Haraguchi Kohei, Matsubayashi Tadashi, Kawai Toshinao, Shirai Yuya, Wada Taizo
Abstract excerpt
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by molecular defects in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. p67phox-CGD is an autosomal recessive CGD, which is caused by a defect in the cytosolic components of NADPH oxidase, p67phox, encoded by NCF2. We previously established a flow cytometric analysis for p67phox expression, which allows accurate...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Male
- Flow Cytometry
- Genotype
- Granulocytes
- Granulomatous Disease, Chronic
- Monocytes