Article
Clinical, Immunological, and Molecular Findings of Patients with p47phox Defect Chronic Granulomatous Disease (CGD) in Indian Families.
Journal of clinical immunology - 1 Nov 2016
Kulkarni Manasi, Desai Mukesh, Gupta Maya, Dalvi Aparna, Taur Prasad, Terrance Antony, Bhat Sunil, Manglani Mamta, Raj Revathi, Shah Ira, Madkaikar Manisha
Abstract excerpt
Chronic granulomatous disease (CGD) is a group of inherited disorder of phagocytes, resulting from mutations in the components of the NADPH oxidase complex. Reduced or absent oxygen radical synthesis seen in these patients leads to impaired killing of intracellular bacteria and fungi. CGD clinically presents with recurrent and life-threatening infections as well as granulomatous inflammatory responses. p47phox...
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