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Article

Chronic granulomatous disease.

Current opinion in immunology - 1 Oct 2003

Heyworth Paul G, Cross Andrew R, Curnutte John T

Abstract excerpt

Chronic granulomatous disease (CGD) is a primary immunodeficiency that affects phagocytes of the innate immune system and is characterized by a greatly increased susceptibility to severe bacterial and fungal infections. CGD is caused by mutations in any one of four genes that encode the subunits of phagocyte NADPH oxidase, the enzyme that generates microbicidal (and pro-inflammatory) oxygen radicals. Of the 410...

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Identifiers

PMID: 14499268
DOI: 10.1016/s0952-7915(03)00109-2

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