Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras- and Raf-mediated regulation of transforming growth factor beta 1 gene expression by ligands of tyrosine kinase receptors in PC12 cells.

Oncogene - 20 Jun 1996

Cosgaya J M, Aranda A

Abstract excerpt

Different ligands of tyrosine kinase receptors have neurotrophic or mitogenic effects in PC12 cells. NFG and FGF, which cause morphological differentiation, as well as EGF, that induces cell growth, produce a significant increase of TGF-beta1 transcripts in PC12 cells. Sequences responsible for t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Culture Media
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, ras

Share to Mutation

Share to Proto-Oncogene Proteins

Share to RNA, Messenger

Source

Identifiers

PMID: 8700524

Genes

EGF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8700524-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras- and Raf-mediated regulation of transforming growth factor beta 1 gene expression by ligands of tyrosine kinase receptors in PC12 cells.PMID 8700524Read ↗

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.Semantic proximity Read ↗

Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons.Semantic proximity Read ↗

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor.Semantic proximity Read ↗

Activation of Ras, Raf-1 and protein kinase C in differentiating human neuroblastoma cells after treatment with phorbolester and NGF.Semantic proximity Read ↗

Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.Semantic proximity Read ↗

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.Semantic proximity Read ↗

Fibroblast growth factor receptor 3 induces gene expression primarily through Ras-independent signal transduction pathways.Semantic proximity Read ↗

The signal transduction pathway underlying ion channel gene regulation by SP1-C-Jun interactions.Semantic proximity Read ↗

Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.Semantic proximity Read ↗

Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.