Article
Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.
The Journal of biological chemistry - 15 Sept 2017
Renart M Lourdes, Montoya Estefanía, Giudici A Marcela, Poveda José A, Fernández Asia M, Morales Andrés, González-Ros José M
Abstract excerpt
The selectivity filter in potassium channels, a main component of the ion permeation pathway, configures a stack of binding sites (sites S1-S4) to which K+ and other cations may bind. Specific ion binding to such sites induces changes in the filter conformation, which play a key role in defining both selectivity and permeation. Here, using the potassium channel KcsA as a model, we contribute new evidence to...
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