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Article

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels.

Nature - 11 Nov 1993

Yang J, Ellinor P T, Sather W A, Zhang J F, Tsien R W

Abstract excerpt

Voltage-gated Ca2+ channels link changes in membrane potential to the delivery of Ca2+, a key second messenger for many cellular responses. Ca2+ channels show selectivity for Ca2+ over more plentiful ions such as Na+ or K+ by virtue of their high-affinity binding of Ca2+ within the pore. It has b...

Topics

Amino Acid Sequence
Animals
Calcium
Calcium Channels
Cell Membrane Permeability
Cells, Cultured
Glutamates
Ions
Molecular Sequence Data
Mutation
Myocardium
Rabbits
Xenopus

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Identifiers

PMID: 8232554
DOI: 10.1038/366158a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8232554-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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