Article
Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays.
Journal of immunological methods - 28 Feb 2011
Lu Yanmei, Vernes Jean-Michel, Chiang Nancy, Ou Qinglin, Ding Jiabing, Adams Camellia, Hong Kyu, Truong Bao-Tran, Ng Domingos, Shen Amy, Nakamura Gerald, Gong Qian, Presta Leonard G, Beresini Maureen, Kelley Bob, Lowman Henry, Wong Wai Lee, Meng Y Gloria
Abstract excerpt
Clinical response to the anti-CD20 antibody rituximab has been demonstrated to correlate with the polymorphism in the FcγRIIIa receptor where patients homozygous for the higher affinity V158 allotype showed a better response rate. This finding suggests that engineering of anti-CD20 for increased...
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