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Article

FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome treated with immunochemotherapy: a meta-analysis on 1134 patients from two prospective cohorts.

Hematological oncology - 1 Dec 2017

Ghesquières Hervé, Larrabee Beth R, Haioun Corinne, Link Brian K, Verney Aurélie, Slager Susan L, Ketterer Nicolas, Ansell Stephen M, Delarue Richard, Maurer Matthew J, Fitoussi Olivier, Habermann Thomas M, Peyrade Fréderic, Dogan Ahmet, Molina Thierry J, Novak Anne J, Tilly Hervé, Cerhan James R, Salles Gilles

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in FCγ-receptor genes FCGR3A (rs396991) and FCGR2A (rs1801274) influence the affinity of the Fc portion of anti-CD20 immunoglobulin G1 monoclonal antibody. Their roles in diffuse large B-cell lymphoma (DLBCL) treated with rituximab in combination with anthracycline-based chemotherapy remain controversial. To address this question, we genotyped FCGR2A and FCGR3A SNPs in two...

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Share to Cohort Studies
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Share to Lymphoma, Large B-Cell, Diffuse
Share to Polymorphism, Genetic
Share to Polymorphism, Single Nucleotide
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Share to Receptors, IgG

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Identifiers

PMID: 27282998
DOI: 10.1002/hon.2305
PMCID: PMC5716925

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EFS

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FCGR3A/2A polymorphisms and diffuse large B-cell lymphoma outcome treated with immunochemotherapy: a meta-analysis on 1134 patients from two prospective cohorts.PMID 27282998Read ↗

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