Article
Genetic linkage of Fc gamma RIIa and Fc gamma RIIIa and implications for their use in predicting clinical responses to CD20-directed monoclonal antibody therapy.
Clinical lymphoma & myeloma - 1 Jan 2007
Hatjiharissi Evdoxia, Hansen Mark, Santos Daniel Ditzel, Xu Lian, Leleu Xavier, Dimmock Elizabeth W, Ho Allen W, Hunter Zachary R, Branagan Andrew R, Patterson Christopher J, Kortsaris Alexandros, Verselis Sigitas, Fox Edward, Treon Steven P
Abstract excerpt
BACKGROUND: Polymorphisms in FcgammaRIIa and FcgammaRIIIa receptors are associated with responses to the CD20-directed immunoglobulin G1 (IgG1) monoclonal antibody rituximab among patients with indolent lymphoma. At odds with the aforementioned clinical observations has been the finding that IgG1 binding is impacted by polymorphisms in FcgammaRIIIa but not FcgammaRIIa. One possibility for this discrepancy might...
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