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Article

Fc Receptor Variants and Disease: A Crucial Factor to Consider in the Antibody Therapeutics in Clinic.

International journal of molecular sciences - 31 Aug 2021

Kim Jin, Lee Ji Young, Kim Han Gil, Kwak Min Woo, Kang Tae Hyun

Abstract excerpt

The fragment crystallizable (Fc) domain of antibodies is responsible for their protective function and long-lasting serum half-life via Fc-mediated effector function, transcytosis, and recycling through its interaction with Fc receptors (FcRs) expressed on various immune leukocytes, epithelial, and endothelial cells. Therefore, the Fc-FcRs interaction is a control point of both endogenous and therapeutic antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34502398
DOI: 10.3390/ijms22179489
PMCID: PMC8431278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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