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Article

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene.

Blood - 1 Feb 2002

Cartron Guillaume, Dacheux Laurent, Salles Gilles, Solal-Celigny Philippe, Bardos Pierre, Colombat Philippe, Watier Hervé

Abstract excerpt

Given that the FcgammaRIIIa receptor 158V allotype displays a higher affinity for human immunoglobulin G1 and increased antibody-dependent cellular cytotoxicity, the aim of this study was to determine the influence of that FCGR3A polymorphism on the therapeutic response to rituximab, an anti-CD20 humanized immunoglobulin G1 increasingly used in the treatment of non-Hodgkin lymphomas. The FCGR3A-158V/F genotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal, Murine-Derived
Share to Antigens, CD20

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Genes, bcl-2

Share to Lymphoma, Follicular

Share to Multivariate Analysis

Share to Receptors, IgG

Share to Rituximab

Source

Identifiers

PMID: 11806974
DOI: 10.1182/blood.v99.3.754

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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