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Article

Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors.

mAbs - 1 Jan 2024

Hale Geoff, De Vos Jelle, Davy Alastair Douglas, Sandra Koen, Wilkinson Ian

Abstract excerpt

Elimination of the binding of immunoglobulin Fc to Fc gamma receptors is highly desirable for the avoidance of unwanted inflammatory responses to therapeutic antibodies and fusion proteins. Many different approaches have been used in the clinic, but they have not been systematically compared. We have now produced a matched set of anti-CD20 antibodies with different Fc subclasses and variants and compared their...

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Share to Antibodies, Monoclonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39279104
DOI: 10.1080/19420862.2024.2402701
PMCID: PMC11407402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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