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Article

Tubular overexpression of gremlin induces renal damage susceptibility in mice.

PloS one - 1 Jan 2014

Droguett Alejandra, Krall Paola, Burgos M Eugenia, Valderrama Graciela, Carpio Daniel, Ardiles Leopoldo, Rodriguez-Diez Raquel, Kerr Bredford, Walz Katherina, Ruiz-Ortega Marta, Egido Jesus, Mezzano Sergio

Abstract excerpt

A growing number of patients are recognized worldwide to have chronic kidney disease. Glomerular and interstitial fibrosis are hallmarks of renal progression. However, fibrosis of the kidney remains an unresolved challenge, and its molecular mechanisms are still not fully understood. Gremlin is an embryogenic gene that has been shown to play a key role in nephrogenesis, and its expression is generally low in the...

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Source

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Identifiers

PMID: 25036148
DOI: 10.1371/journal.pone.0101879
PMCID: PMC4103765

Genes

GREM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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