Article
Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2011
Garzón-Ospina Diego, Romero-Murillo Liza, Tobón Luisa F, Patarroyo Manuel A
Abstract excerpt
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic...
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