Article
Correlation of OAS1 gene polymorphism at exon 7 splice accepter site with interferon-based therapy of HCV infection in Pakistan.
Viral immunology - 1 Apr 2014
Imran Muhammad, Manzoor Sobia, Khattak Nasir Mahmood, Tariq Muqddas, Khalid Madiha, Javed Farakh, Bhatti Shameem
Abstract excerpt
The most useful treatment for HCV infection worldwide is peg-interferon plus ribavirin, although the response varies from person to person. Hence, host genetics are significantly involved in the treatment response to HCV infection. The 2'-5' oligoadenylate synthetase (OAS) is one of the most important components of the immune system having significant antiviral functions. The aim of this study was to investigate...
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