Article
Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C.
Journal of hepatology - 1 Aug 2008
Su Xiaowen, Yee Leland J, Im KyungAh, Rhodes Shannon L, Tang YongMing, Tong Xiaomei, Howell Charles, Ramcharran Darmendra, Rosen Hugo R, Taylor Milton W, Liang T Jake, Yang Huiying
Abstract excerpt
BACKGROUND/AIMS: Interferon signaling pathway genes (IPGs) and interferon-stimulated genes (ISGs) are associated with the host response to hepatitis C virus (HCV) infection. We studied single nucleotide polymorphisms (SNPs) in IPGs and ISGs for their associations with response to pegylated interferon alpha-2a (Peg-IFN-alpha) plus ribavirin therapy in HCV genotype-1 infected patients. METHODS: A two-stage study...
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