Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.

Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2009

Li Chang-Zheng, Kato Naoya, Chang Jin-Hai, Muroyama Ryosuke, Shao Run-Xuan, Dharel Narayan, Sermsathanasawadi Radsamee, Kawabe Takao, Omata Masao

Abstract excerpt

BACKGROUND: Progression of disease after hepatitis C virus (HCV) infection differs among individuals, indicating a possibility of participation of host genetic factors. 2'-5'-oligoadenylate synthetase 1 (OAS-1), an important component of the innate immune system, has an antiviral function, and may therefore have a certain relationship with progression of disease. AIM: To evaluate single nucleotide polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2',5'-Oligoadenylate Synthetase
Share to Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Disease Progression

Share to Hepatitis C, Chronic

Share to Interferons

Share to Liver Cirrhosis

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19515215
DOI: 10.1111/j.1478-3231.2009.02061.x
PMCID: PMC7194156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication.PMID 19515215Read ↗

Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.Semantic proximity Read ↗

Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy.Semantic proximity Read ↗

Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study.Semantic proximity Read ↗

Correlation of OAS1 gene polymorphism at exon 7 splice accepter site with interferon-based therapy of HCV infection in Pakistan.Semantic proximity Read ↗

Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan.Semantic proximity Read ↗

Polymorphisms of interferon-inducible genes OAS associated with interferon-α treatment response in chronic HBV infection.Semantic proximity Read ↗

Three Gene Signature for Predicting the Development of Hepatocellular Carcinoma in Chronically Infected Hepatitis C Virus Patients.Semantic proximity Read ↗

A candidate gene study for the association of host single nucleotide polymorphisms with liver cirrhosis risk in chinese hepatitis B patients.Semantic proximity Read ↗

Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis.Semantic proximity Read ↗

Oligoadenylate synthetase 3 S381R gene polymorphism is associated with severity of EV71 infection in Chinese children.Semantic proximity Read ↗

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in microRNAs with susceptibility to hepatitis B virus infection and HBV-related liver complications: A study in a Saudi Arabian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.