Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.

Carcinogenesis - 1 Dec 1993

Mills K J, Reynolds S H, Smart R C

Abstract excerpt

Diacylglycerols (DAG) are lipid second messengers which are generated during phospholipase-catalyzed hydrolysis of phospholipids. The model DAG, sn-1,2-didecanoylglycerol (DIC10), is an effective topical tumor promoter in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin. We now report that 11/12 of DMBA-initiated/DIC10-promoted papillomas examined contain an A-->T mutation in the 61st codon of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Clone Cells
Share to Genes, ras

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Molecular Sequence Data

Share to Mutation

Share to Oligodeoxyribonucleotides

Source

Identifiers

PMID: 8269640
DOI: 10.1093/carcin/14.12.2645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.PMID 8269640Read ↗

Analysis of ras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice.Semantic proximity Read ↗

Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP.Semantic proximity Read ↗

Harvey-ras gene expression and epidermal cell proliferation in dibenzo[a,l]pyrene-treated early preneoplastic SENCAR mouse skin.Semantic proximity Read ↗

Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.Semantic proximity Read ↗

Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol.Semantic proximity Read ↗

Analysis of point mutations in murine c-Ha-ras of skin tumors initiated with dibenz[a,j]anthracene and derivatives.Semantic proximity Read ↗

Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.Semantic proximity Read ↗

Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein.Semantic proximity Read ↗

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.Semantic proximity Read ↗

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.Semantic proximity Read ↗

Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.