Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.

doi:10.1093/carcin/14.12.2645

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Article

Diacylglycerol is an effector of the clonal expansion of cells containing activated Ha-ras genes.

Carcinogenesis - 1 Dec 1993

Mills K J, Reynolds S H, Smart R C

Abstract excerpt

Diacylglycerols (DAG) are lipid second messengers which are generated during phospholipase-catalyzed hydrolysis of phospholipids. The model DAG, sn-1,2-didecanoylglycerol (DIC10), is an effective topical tumor promoter in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin. We now report t...

Topics

9,10-Dimethyl-1,2-benzanthracene
Adenine
Animals
Base Sequence
Clone Cells
Decanoic Acids
Diglycerides
Genes, ras
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Papilloma
Second Messenger Systems
Skin Neoplasms
Tetradecanoylphorbol Acetate
Thymine

Source

Open in PubMed

Identifiers

PMID: 8269640
DOI: 10.1093/carcin/14.12.2645

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8269640-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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