Article
Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1992
Nelson M A, Futscher B W, Kinsella T, Wymer J, Bowden G T
Abstract excerpt
An activated Ha-ras oncogene has been consistently found in chemically initiated benign and malignant mouse skin tumors, and an activated ras oncogene has been shown to initiate the process of mouse skin carcinogenesis. However, the exact timing of mutational activation of the Ha-ras gene relative to application of the chemical carcinogen is not known. A sensitive mutation-specific PCR technique was used to...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Acetone
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Genes, ras
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms, Experimental