Article
Role of the Yersinia pestis yersiniabactin iron acquisition system in the incidence of flea-borne plague.
PloS one - 17 Dec 2010
Sebbane Florent, Jarrett Clayton, Gardner Donald, Long Daniel, Hinnebusch B Joseph
Abstract excerpt
Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y. pestis mutants lacking the yersiniabactin (Ybt) siderophore-based iron transport system are avirulent when inoculated intradermally but fully virulent when inoculated intravenously in mice. Presumably, Ybt is required to provide sufficient iron at the peripheral injection site, suggesting that Ybt would be an essential virulence factor...
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