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Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis.

PLoS pathogens - 26 Feb 2010

Vadyvaloo Viveka, Jarrett Clayton, Sturdevant Daniel E, Sebbane Florent, Hinnebusch B Joseph

Abstract excerpt

Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37 degrees C induces many known virulence factors of Y. pestis that confer resistance to innate immunity. These factors are not produced in the...

Topics

Adaptation, Physiological
Animals
Biofilms
Gene Expression
Gene Expression Profiling
Genes, Bacterial
Immunity, Innate
Insect Vectors
Oligonucleotide Array Sequence Analysis
Phenotype
Reverse Transcriptase Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Siphonaptera

Yersinia pestis

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Open in PubMed Open full text

Identifiers

PMID: 20195507
DOI: 10.1371/journal.ppat.1000783
PMCID: PMC2829055

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