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Article

Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis.

PLoS pathogens - 26 Feb 2010

Vadyvaloo Viveka, Jarrett Clayton, Sturdevant Daniel E, Sebbane Florent, Hinnebusch B Joseph

Abstract excerpt

Yersinia pestis, the agent of plague, is transmitted to mammals by infected fleas. Y. pestis exhibits a distinct life stage in the flea, where it grows in the form of a cohesive biofilm that promotes transmission. After transmission, the temperature shift to 37 degrees C induces many known virulence factors of Y. pestis that confer resistance to innate immunity. These factors are not produced in the...

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Source

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Identifiers

PMID: 20195507
DOI: 10.1371/journal.ppat.1000783
PMCID: PMC2829055

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Source receipt: pubmed, retrieved 7 Sept 2026.

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