Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice.

Metallomics : integrated biometal science - 21 Jun 2017

Bobrov Alexander G, Kirillina Olga, Fosso Marina Y, Fetherston Jacqueline D, Miller M Clarke, VanCleave Tiva T, Burlison Joseph A, Arnold William K, Lawrenz Matthew B, Garneau-Tsodikova Sylvie, Perry Robert D

Abstract excerpt

A number of bacterial pathogens require the ZnuABC Zinc (Zn2+) transporter and/or a second Zn2+ transport system to overcome Zn2+ sequestration by mammalian hosts. Previously we have shown that in addition to ZnuABC, Yersinia pestis possesses a second Zn2+ transporter that involves components of the yersiniabactin (Ybt), siderophore-dependent iron transport system. Synthesis of the Ybt siderophore and YbtX, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Gene Expression Regulation, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages, Peritoneal

Share to Plague

Share to Virulence

Share to Virulence Factors

Share to Yersinia pestis

Source

Open in PubMed Open full text

Identifiers

PMID: 28540946
DOI: 10.1039/c7mt00126f
PMCID: PMC5532734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice.PMID 28540946Read ↗

The Y ersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in miceSemantic proximity Read ↗

Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence.Semantic proximity Read ↗

High-Affinity Zn2+Uptake System ZnuABC Is Required for Bacterial Zinc Homeostasis in Intracellular Environments and Contributes to the Virulence ofSalmonella entericaSemantic proximity Read ↗

Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen InterfaceSemantic proximity Read ↗

Zinc Acquisition Mechanisms Differ between Environmental and Virulent Francisella Species.Semantic proximity Read ↗

Zinc Homeostasis at the Bacteria/Host Interface—From Coordination Chemistry to Nutritional ImmunitySemantic proximity Read ↗

Competition for zinc binding in the host-pathogen interactionSemantic proximity Read ↗

Acinetobacter baumannii response to host-mediated zinc limitation requires the transcriptional regulator Zur.Semantic proximity Read ↗

Identification of zinc-dependent mechanisms used by Group B <i>Streptococcus</i> to overcome calprotectin-mediated stressSemantic proximity Read ↗

Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosisSemantic proximity Read ↗

The Role of Zinc Efflux during Acinetobacter baumannii InfectionSemantic proximity Read ↗

Cellular management of Zinc in group B <i>Streptococcus</i> supports bacterial resistance against metal intoxication and promotes disseminated infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.