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Article

Silencing urease: a key evolutionary step that facilitated the adaptation of Yersinia pestis to the flea-borne transmission route.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2014

Chouikha Iman, Hinnebusch B Joseph

Abstract excerpt

The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity to the flea vectors of plague, whereas Y. pestis does not. In this study, we identify the Yersinia urease enzyme as...

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Identifiers

PMID: 25453069
DOI: 10.1073/pnas.1413209111
PMCID: PMC4284590

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