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Article

Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.

The Journal of biological chemistry - 19 Jul 2013

Ebel Philipp, Vom Dorp Katharina, Petrasch-Parwez Elisabeth, Zlomuzica Armin, Kinugawa Kiyoka, Mariani Jean, Minich David, Ginkel Christina, Welcker Jochen, Degen Joachim, Eckhardt Matthias, Dere Ekrem, Dörmann Peter, Willecke Klaus

Abstract excerpt

The N-acyl chain length of ceramides is determined by the specificity of different ceramide synthases (CerS). The CerS family in mammals consists of six members with different substrate specificities and expression patterns. We have generated and characterized a mouse line harboring an enzymatically inactive ceramide synthase 6 (CerS6KO) gene and lacz reporter cDNA coding for β-galactosidase directed by the CerS6...

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Identifiers

PMID: 23760501
DOI: 10.1074/jbc.M113.479907
PMCID: PMC3774410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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