Article
A novel mitochondrial sphingomyelinase in zebrafish cells.
The Journal of biological chemistry - 24 Jul 2009
Yabu Takeshi, Shimuzu Akio, Yamashita Michiaki
Abstract excerpt
Sphingolipids are important signaling molecules in many biological processes, but little is known regarding their physiological roles in the mitochondrion. We focused on the biochemical characters of a novel sphingomyelinase (SMase) and its function in mitochondrial ceramide generation in zebrafish embryonic cells. The cloned SMase cDNA encoded a polypeptide of 545 amino acid residues (putative molecular weight,...
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