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Article

Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.

Journal of pediatric gastroenterology and nutrition - 1 Nov 2008

Ohlsson Lena, Hjelte Lena, Hühn Michael, Scholte Bob J, Wilke Martina, Flodström-Tullberg Malin, Nilsson Ake

Abstract excerpt

OBJECTIVES: The intestinal brush border enzymes alkaline sphingomyelinase (alk-SMase) and neutral ceramidase (CDase) digest milk sphingomyelin in suckling neonates. In addition, alk-SMase, CDase, and acid sphingomyelinase (acid-SMase) have been implicated in sphingolipid signaling, which exhibits abnormalities in cystic fibrosis (CF). In this study, we tested the hypothesis that the expression of these enzymes is...

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Identifiers

PMID: 18955860
DOI: 10.1097/MPG.0b013e3181826daf

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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