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Article

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

The Journal of biological chemistry - 12 Nov 2010

Jenkins Russell W, Canals Daniel, Idkowiak-Baldys Jolanta, Simbari Fabio, Roddy Patrick, Perry David M, Kitatani Kazuyuki, Luberto Chiara, Hannun Yusuf A

Abstract excerpt

The acid sphingomyelinase (aSMase) gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory sphingomyelinase (S-SMase), via differential trafficking of a common protein precursor. However, the regulation of S-SMase and its role in cytokine-induced ceramide formation remain ill defined. To determine the role of S-SMase in cellular sphingolipid metabolism, MCF7 breast carcinoma...

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Identifiers

PMID: 20807762
DOI: 10.1074/jbc.M110.125609
PMCID: PMC2975195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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