Time course of hepatic lipids accumulation in a strain of mice with an inherited deficiency of sphingomyelinase.

doi:10.1093/oxfordjournals.jhered.a109840

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Article

Time course of hepatic lipids accumulation in a strain of mice with an inherited deficiency of sphingomyelinase.

The Journal of heredity - 1 Jan 2000

Miyawaki S, Mitsuoka S, Sakiyama T, Kitagawa T

Abstract excerpt

Sphingomyelinosis (gene symbol, spm) is a recessive autosomal mutation in mice that causes a condition analogous to the human disease known as Niemann-Pick disease. The time course of hepatic lipids accumulation in this murine model was investigated. Hepatosplenomegaly in spm/ spm mice was notice...

Topics

Age Factors
Animals
Disease Models, Animal
Genes, Recessive
Lipid Metabolism
Liver
Male
Mice
Mice, Inbred C57BL
Mutation
Phosphoric Diester Hydrolases
Sphingomyelin Phosphodiesterase

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