Article
A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.
Genes & development - 1 Dec 1991
Rockmill B, Roeder G S
Abstract excerpt
The mek1 (meiotic kinase) mutant of Saccharomyces cerevisiae was isolated in a screen for sporulation-proficient, meiotic-lethal mutants. Diploids homozygous for a mek1 null mutation produce only 13% viable spores. mek1 spore inviability is rescued by a spo13 mutation, which causes cells to bypass the meiosis I division. In a mek1 null mutant, meiotic recombination is reduced but not completely eliminated....
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Fungal
- Genes, Fungal
- Meiosis
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Recombination, Genetic
- Saccharomyces cerevisiae
- Synaptonemal Complex