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Article

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.

Molecular biology of the cell - 1 Jan 2004

Wan Lihong, de los Santos Teresa, Zhang Chao, Shokat Kevan, Hollingsworth Nancy M

Abstract excerpt

Three meiosis-specific chromosomal components in budding yeast, Mek1, Red1, and Hop1, are required for recombination, proper segregation of homologs, and the meiotic recombination checkpoint. Mek1 is a protein kinase. Mutations that increase the size of the ATP binding pocket of Mek1 (mek1-as1) sensitize the kinase to specific small molecule inhibitors. Experiments using mek1-as1 demonstrate that the requirement...

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Identifiers

PMID: 14595109
DOI: 10.1091/mbc.e03-07-0499
PMCID: PMC307523

Genes

DMC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.PMID 14595109Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Semantic proximity Read ↗

Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response.Semantic proximity Read ↗

Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.Semantic proximity Read ↗

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.Semantic proximity Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.Semantic proximity Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.Semantic proximity Read ↗

A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.Semantic proximity Read ↗

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