Article
Pachytene exit controlled by reversal of Mek1-dependent phosphorylation.
Cell - 14 Apr 2000
Bailis J M, Roeder G S
Abstract excerpt
During yeast meiosis, a checkpoint prevents exit from pachytene in response to defects in meiotic recombination and chromosome synapsis. This pachytene checkpoint requires two meiotic chromosomal proteins, Red1 and Mek1; Mek1 is a kinase that phosphorylates Red1. In mutants that undergo checkpoint-mediated pachytene arrest, Mek1 is active and Red1 remains phosphorylated. Activation of Mek1 requires the initiation...
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