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Article

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.

Molecular biology of the cell - 1 Dec 2005

Niu Hengyao, Wan Lihong, Baumgartner Bridget, Schaefer Dana, Loidl Josef, Hollingsworth Nancy M

Abstract excerpt

Meiotic recombination differs from mitotic recombination in that DSBs are repaired using homologous chromosomes, rather than sister chromatids. This change in partner choice is due in part to a barrier to sister chromatid repair (BSCR) created by the meiosis-specific kinase, Mek1, in a complex with two other meiosis-specific proteins, Hop1 and Red1. HOP1 contains two functional domains, called the N and C...

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Identifiers

PMID: 16221890
DOI: 10.1091/mbc.e05-05-0465
PMCID: PMC1289423

Genes

DMC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.PMID 16221890Read ↗

Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.Semantic proximity Read ↗

Organizational principles governing assembly and activation of the meiosis-specific Red1-Hop1-Mek1 complexSemantic proximity Read ↗

Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.Semantic proximity Read ↗

Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p.Semantic proximity Read ↗

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Semantic proximity Read ↗

Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response.Semantic proximity Read ↗

Red1p, a MEK1-dependent phosphoprotein that physically interacts with Hop1p during meiosis in yeast.Semantic proximity Read ↗

Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.Semantic proximity Read ↗

Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Semantic proximity Read ↗

A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination.Semantic proximity Read ↗

Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.Semantic proximity Read ↗

Bypass of a meiotic checkpoint by overproduction of meiotic chromosomal proteins.Semantic proximity Read ↗

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