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Article

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2011

Barber Daniel L, Mayer-Barber Katrin D, Feng Carl G, Sharpe Arlene H, Sher Alan

Abstract excerpt

Although CD4 T cells are required for host resistance to Mycobacterium tuberculosis, they may also contribute to pathology. In this study, we examine the role of the inhibitory receptor PD-1 and its ligand PD-L1 during M. tuberculosis infection. After aerosol exposure, PD-1 knockout (KO) mice dev...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21172867
DOI: 10.4049/jimmunol.1003304
PMCID: PMC4059388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21172867-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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