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PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

8 Jan 2021

Abstract excerpt

(Mtb) infection of rhesus macaques. Animals treated with anti-PD-1 monoclonal antibody developed worse disease and higher granuloma bacterial loads compared with isotype control-treated monkeys. PD-1 blockade increased the number and functionality of granuloma Mtb-specific CD8 T cells. In contrast, Mtb-specific CD4 T cells in anti-PD-1-treated macaques were not increased in number or function in granulomas,...

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PMID: 33452107
DOI: 10.1126/sciimmunol.abf3861

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