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Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis

29 Jul 2024

Abstract excerpt

Abstract The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, its effect on PD-L1 expression in macrophages after MTB infection remains unknown. We prospectively enrolled patients with active tuberculosis (TB) and non-TB subjects....

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PMID: 39081906
DOI: 10.15698/mic2024.07.832

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