Article
T cell receptor interactions with class I heavy-chain influence T cell selection.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000
Kuhns S T, Tallquist M D, Johnson A J, Mendez-Fernandez Y, Pease L R
Abstract excerpt
The interaction of the T cell receptor (TCR) with peptide in the binding site of the major histocompatibility complex molecule provides the basis for T cell recognition during immune surveillance, repertoire development, and tolerance. Little is known about the extent to which repertoire selection is influenced directly by variation of the structure of the class I heavy chain. We find that the 2C TCR, normally...
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