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Article

The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant.

European journal of immunology - 1 Nov 1990

Nikolić-Zugić J, Carbone F R

Abstract excerpt

The H-2Kb-restricted cytotoxic T lymphocyte (CTL) response directed against ovalbumin (OVA) is specific for a region contained within the sequence OVA253-276. In this study we have characterized this response by examining the class I-restricted presentation of OVA peptides by the naturally occurr...

Topics

Animals
Binding Sites
Clone Cells
Female
H-2 Antigens
Histocompatibility Antigens Class I
Mice
Mutation
Ovalbumin
Protein Conformation
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2253683
DOI: 10.1002/eji.1830201111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2253683-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant.PMID 2253683Read ↗

Peptide variants reveal how antibodies recognize major histocompatibility complex class I.Semantic proximity Read ↗

Alloreactive cytotoxic T lymphocytes recognize epitopes determined by both the alpha helices and beta sheets of the class I peptide binding site.Semantic proximity Read ↗

Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.Semantic proximity Read ↗

Peptide affinity for MHC influences the phenotype of CD8(+) T cells primed in vivo.Semantic proximity Read ↗

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.Semantic proximity Read ↗

Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptidesSemantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference.Semantic proximity Read ↗

A conservative mutation in a class I MHC molecule outside the peptide binding groove stimulates responses to self peptides.Semantic proximity Read ↗

Alloreactive monoclonal antibodies select Kd molecules with different peptide profiles.Semantic proximity Read ↗

A single amino acid substitution in the H-2Kb molecule generates a defined allogeneic epitope.Semantic proximity Read ↗

Low binding capacity of murine tetramers mutated at residue 227 does not preclude the ability to efficiently activate CD8+ T lymphocytes.Semantic proximity Read ↗

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