Transplantation effects of a unique major histocompatibility complex class I mutation.

Abstract excerpt

This study describes a novel MHC class I mouse mutant that was discovered because of loss of reactivity of its cells to monoclonal antibodies. The mutation occurred in the H-2Ks molecule and is the first in vivo mutation described that has a single altered amino acid residue (amino acid 107) distant from the regions considered to be peptide or TCR contacts. Nevertheless, skin grafts from the mutant to the parent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytotoxicity, Immunologic
• Share to Genes, MHC Class I
• Share to H-2 Antigens