Article
Transplantation effects of a unique major histocompatibility complex class I mutation.
Transplantation - 1 Aug 1992
Hasenkrug K J, Stimpfling J H, Winn H J, Nathenson S G
Abstract excerpt
This study describes a novel MHC class I mouse mutant that was discovered because of loss of reactivity of its cells to monoclonal antibodies. The mutation occurred in the H-2Ks molecule and is the first in vivo mutation described that has a single altered amino acid residue (amino acid 107) distant from the regions considered to be peptide or TCR contacts. Nevertheless, skin grafts from the mutant to the parent...
Topics
- Animals
- Cytotoxicity, Immunologic
- Genes, MHC Class I
- H-2 Antigens
- Immune Tolerance
- Immunity, Cellular
- Mice
- Mutation
- Skin Transplantation
- T-Lymphocytes, Cytotoxic