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Article

A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.

American journal of human genetics - 1 Feb 2024

Chong Amanda Y, Brenner Nicole, Jimenez-Kaufmann Andres, Cortes Adrian, Hill Michael, Littlejohns Thomas J, Gilchrist James J, Fairfax Benjamin P, Knight Julian C, Hodel Flavia, Fellay Jacques, McVean Gil, Moreno-Estrada Andres, Waterboer Tim, Hill Adrian V S, Mentzer Alexander J

Abstract excerpt

Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38232728
DOI: 10.1016/j.ajhg.2023.12.013
PMCID: PMC10870136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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