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Article

Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.

Molecular biology reports - 1 Nov 2011

Naushad Shaik Mohammad, Pavani Addepalli, Digumarti Raghunadha Rao, Gottumukkala Suryanarayana Raju, Kutala Vijay Kumar

Abstract excerpt

In view of growing body of evidence substantiating the role of aberrations in one-carbon metabolism in the pathophysiology of breast cancer and lack of studies on gene-gene interactions, we investigated the role of dietary micronutrients and eight functional polymorphisms of one-carbon metabolism in modulating the breast cancer risk in 244 case-control pairs of Indian women and explored possible gene-gene...

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Source

Identifiers

PMID: 21161404
DOI: 10.1007/s11033-010-0631-z

Genes

MTHFR
TYMS
RFC1
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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