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Article

Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.

Molecular biology reports - 1 Jul 2015

Naushad Shaik Mohammad, Vijayalakshmi Sana Venkata, Rupasree Yedluri, Kumudini Nadella, Sowganthika Sampathkumar, Naidu Janardhanan Venketlakshmi, Ramaiah M Janaki, Rao Dunna Nageswara, Kutala Vijay Kumar

Abstract excerpt

Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary artery disease (CAD) and Parkinson's disease (PD). Multifactor dimensionality reduction analysis...

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Identifiers

PMID: 25648260
DOI: 10.1007/s11033-015-3856-z

Genes

CAD
MTRR
COMT
GSTT1
MTHFR
RFC1
TYMS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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