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Article

Genetic determination of fragile-site expression.

American journal of human genetics - 1 Aug 1990

Smeets D, Arets A

Abstract excerpt

To explore genetic effects on the expression of chromosomal fragile sites in vitro, we studied the expression of common fragile sites (c-fra) in cultured lymphocytes of a human chimera (Chi46,XX/46,XY). Since the two cell lines in the chimera share the same environment in vitro and in vivo on cell culture preceding chromosome analysis, differences in the expression of c-fra must be due to genetic factors. The...

Topics

Aphidicolin
Cell Line
Chimera
Chromosome Fragile Sites
Chromosome Fragility
Culture Media
Diterpenes
Female
Gene Expression Regulation
Genetic Markers
Genotype
Humans

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PMID: 2116087
PMCID: PMC1683704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2116087-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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