Article
The expression frequency of common fragile sites and genetic predisposition to colon cancer.
Cancer genetics and cytogenetics - 1 Jun 2000
Tunca B, Egeli U, Zorluoglu A, Yilmazlar T, Yerci O, Kizil A
Abstract excerpt
The expression frequency of common fragile sites induced by aphidicolin (Apc), bromodeoxyuridine (BrdU), and caffeine was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 32 patients with colon cancer, 30 of their clinically healthy family members and 30 age-matched normal controls. The proportion of damaged cells (P < 0.001), the mean number of chromosomal aberrations and...
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