Common fragile site expression and genetic predisposition to breast cancer.

doi:10.1002/(sici)1520-6866(1998)18:6<279::aid-tcm2>3.3.co;2-l

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Article

Common fragile site expression and genetic predisposition to breast cancer.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1998

Ceçener G, Egeli U, Taşdelen I, Tunca B, Duman H, Kizil A

Abstract excerpt

The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex- and age-matched normal controls. As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression...

Topics

Aphidicolin
Breast Neoplasms
Caffeine
Chromosome Aberrations
Chromosome Fragile Sites
Chromosome Fragility
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Lymphocytes
Pedigree
Risk Factors

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Identifiers

PMID: 10052563
DOI: 10.1002/(sici)1520-6866(1998)18:6<279::aid-tcm2>3.3.co;2-l

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