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Article

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.

Blood - 15 Apr 2008

Wynn Katherine K, Fulton Zara, Cooper Leanne, Silins Sharon L, Gras Stephanie, Archbold Julia K, Tynan Fleur E, Miles John J, McCluskey James, Burrows Scott R, Rossjohn Jamie, Khanna Rajiv

Abstract excerpt

CD8(+) T-cell responses to persistent viral infections are characterized by the accumulation of an oligoclonal T-cell repertoire and a reduction in the naive T-cell pool. However, the precise mechanism for this phenomenon remains elusive. Here we show that human cytomegalovirus (HCMV)-specific CD8(+) T cells recognizing distinct epitopes from the pp65 protein and restricted through an identical HLA class I allele...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18270323
DOI: 10.1182/blood-2007-11-122622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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